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Jun, Fri, 2025
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Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the structural basis of how small molecules block its entry into host cells remains unclear.…

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Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

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Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Purchase & Order

Jun, Fri, 2025
Innova1

Beyond the crystal: Dynamic model captures loop flexibility in swine virus drug design

Synthesized peptides can slip into cells to block hard-to-target protein interactions
Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because typical "small-molecule" drugs often prove to be too small to grip the broad, flat surfaces involved in protein-protein interactions.
'Bio-stickers' speed up plastic breakdown in marine environments
Plastic waste poses an urgent problem for the planet's ecosystems, especially in waterways. Millions of tons of plastic waste enter Earth's oceans every year, and plastic has been found in every part of the ocean, including at the bottom of the deepest ocean trenches.
Revised mushroom toxin pathway could improve poisoning detection
The St. George's mushroom (Calocybe gambosa) is a popular edible mushroom, usually picked in May. Unfortunately, however, it also carries a risk as it can easily be confused with the young deadly fiber cap, which can potentially lead to fatal poisoning. The reason for this is the mushroom toxin muscarine, which is present in high concentrations in the deadly fiber cap. Muscarine is best known from the fly agaric, in which it was first discovered.
New biosynthesis platform could enable bioactive compounds to be labeled, targeted and released on demand
Many medically important drugs originate from natural sources. Microorganisms produce these compounds using highly sophisticated and remarkably precise enzymatic assembly lines. Many natural microbial products belong to a class known as nonribosomal peptides—short chains of amino acids that often possess pharmacologically relevant biological activities, including antibiotic effects.
Protein shape mapping could detect diseases before symptoms appear
A University of Mississippi professor and his team have developed a technology that may one day lead to the early diagnosis of juvenile diabetes and CTE caused by traumatic brain injuries. The technology allows researchers to see and label protein shapes and interactions in mammal blood that can possibly lead to an earlier diagnosis of disease before a person even shows symptoms.