Flexible DNA directs proteins into atomically ordered crystals, overturning crystallization assumptions

Jul, Wed, 2026
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For decades, scientists have largely relied on painstaking trial and error to coax proteins into crystalline forms. Crystallization enables scientists to determine the molecular structures of proteins, which can provide a blueprint for designing drugs, engineering enzymes and understanding disease.

Stable DNA building blocks enable faster oligonucleotide synthesis without oxidation
The chemical synthesis of oligonucleotides (ONs) is central to modern molecular biology, diagnostics and nucleic acid therapeutics. While demand for high-quality ONs is increasing, the conventional synthetic method has long-standing efficiency challenges. Widely adopted P(III)-phosphoramidite-based ON synthesis requires an oxidation step after every nucleotide coupling cycle and uses moisture-sensitive building blocks, adding complexity to the workflow and slowing the process.
Flexible DNA directs proteins into atomically ordered crystals, overturning crystallization assumptions
For decades, scientists have largely relied on painstaking trial and error to coax proteins into crystalline forms. Crystallization enables scientists to determine the molecular structures of proteins, which can provide a blueprint for designing drugs, engineering enzymes and understanding disease.
Plant-derived lignin could guide bone repair by forming bone-like minerals
A naturally abundant plant material best known for giving trees and crops their strength may one day help repair broken bones, according to a new study led by postdoctoral researcher Dr. Srinath Palakurthy and Professor Rivka Elbaum of the Hebrew University of Jerusalem.
When polymers meet primitive membranes: How molecular cooperation may have helped life begin
A new study suggests that simple molecules on early Earth may have worked together to create more stable, cell-like structures, offering fresh clues about one of science's biggest questions: how life began. Led by Dr. Moran Frenkel-Pinter of Hebrew University and her postdoctoral researcher, Dr. Rotem Edri, the research shows that two types of simple molecules, fatty acids and hydroxy acids, can combine to create structures that are stronger and more stable than either molecule can form alone.
Biomolecular condensates reveal surprising activity as catalysts
Biomolecular condensates are ubiquitous in living cells, including bacteria, viruses, plants and mammalian systems. These membraneless bodies, or molecular communities made up of DNA, RNA and proteins, are where molecules large and small within the cell come together to coordinate various biochemical reactions.