Molecule activated by cobalt targets DNA three-way junctions linked to cancer

Jul, Wed, 2025
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During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three-way junction (3WJ). These configurations form a well-defined central cavity capable of hosting molecules with specific shapes and properties. Because of their role in cellular processes linked to cancer, 3WJs are gaining attention as promising molecular targets for next-generation therapeutic approaches.

Water molecule unlocks faster interfacial polymerization by lowering energy barrier
Researchers at The Hong Kong University of Science and Technology (HKUST) have achieved two major breakthroughs in interfacial polymerization, a key technique for preparing advanced functional materials. By integrating quantum mechanics with machine learning, the team has elucidated the mechanism by which water molecules facilitate reactions at the molecular level. At the same time, it has transformed microcapsule design from a traditional trial-and-error approach into a predictive science.
One photon, two reactions—new catalyst converts CO₂ and biowaste simultaneously
Researchers have developed a solar-driven catalyst material that harnesses the energy of a single photon to reduce carbon dioxide and oxidize organic waste at the same time, producing valuable chemicals in both reactions.
A pectin and chitosan film to protect bioactive compounds in foods and therapies
Researchers at IMDEA Materials Institute and the Institute of Polymer Science and Technology (ICTP-CSIC) have developed an innovative biodegradable multilayer film capable of protecting and controlling the release of anthocyanins inside the body. Published in the International Journal of Biological Macromolecules, this innovation opens the door to more effective functional foods and supplements for intestinal health.
Chemists unlock first total synthesis of rare plant alkaloid tied to anticancer activity
Plants are undeniably one of nature's most promising sources of new medicines, with monoterpenoid indole alkaloids (MIAs) being a great example. Some intricate compounds are built from multiple-linked chemical units that form highly complex three-dimensional structures. Because of their size and shape, scientists believe such oligomeric MIAs may be able to interfere with specific protein–protein interactions inside cells—a biological target that conventional small-molecule drugs often struggle to reach.
Secondary silylium ion drives one-pot ketone sulfonamidation, reaching 95% yields
A research team has developed a novel organocatalysis method based on a silylium Lewis acid. This technology employs an ion-pair catalyst combining a diethylsilylium ion with a weakly coordinating anion, enabling the direct installation of sulfonamide groups into functionalized ketone compounds, including β-ketoesters, which had previously been difficult to react using conventional catalytic methods.