Researchers develop a new prodrug and localized drug delivery platform for selective treatment of cancer

Jun, Thu, 2026
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A new collaborative study reports the discovery and application of a novel therapeutic strategy to selectively target EGFR and other kinases with controlled release in tumor microenvironments to improve therapeutic efficacy, with promising results. The research is published in Bioorganic Chemistry.

Researchers develop a new prodrug and localized drug delivery platform for selective treatment of cancer
A new collaborative study reports the discovery and application of a novel therapeutic strategy to selectively target EGFR and other kinases with controlled release in tumor microenvironments to improve therapeutic efficacy, with promising results. The research is published in Bioorganic Chemistry.
Tiny water droplets transmutate aniline into pyridine in ambient and catalyst-free conditions
Aniline can now be transformed into pyridine without adding any catalysts, oxidants or toxic reagents. In a recent study published in the Journal of the American Chemical Society, researchers achieved skeletal editing, involving the reorganization of the carbon-nitrogen bonds within an aromatic ring, by turning an aqueous solution of aniline into a mist of microdroplets.
Designer proteins unlock near-infrared and SWIR glow for deeper tissue imaging
Researchers at the National Center for Tumor Diseases (NCT/UCC) in Dresden, including Oliver Bruns and Dr. Bernardo Arús, are participating in an international study that has, for the first time, developed novel proteins for near-infrared (NIR) and short-wave infrared imaging (SWIR). The research was conducted in collaboration with an international team that included chemistry Nobel laureate David Baker, who was honored in 2024 for his work on computational protein design. The study, with shared first authorship, was recently published in the Journal of the American Chemical Society.
Scientists design 'tunable' biomolecules to probe how sugars behave
Sugars are not just a source of energy—they also play a crucial role in how cells communicate, how proteins interact and how materials behave in medicine and industry. But studying these processes is challenging because sugar molecules are structurally complex and difficult to control.
Drug peptides defy shape rules, activating receptors without full spiral form
When many of us think about how drugs work in the body, we may first think about how a drug gets into the body, such as a pill versus an injection. In the Gellman Group at the UW–Madison Department of Chemistry, researchers are instead thinking about how a drug behaves after it reaches its target, which is critical for effective drug performance. The cells in our bodies must receive and respond to information from their environment for healthy function, and when information flow is disrupted, illness can result. Most of the information is contained in molecules that engage with receptor proteins on cell surfaces. Many medicines work by modifying information transfer at specific receptor proteins.