Synthesized peptides can slip into cells to block hard-to-target protein interactions

Jun, Mon, 2026
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Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because typical “small-molecule” drugs often prove to be too small to grip the broad, flat surfaces involved in protein-protein interactions.

Fifty-year protein mystery breaks open as acid-driven water loss comes into view
Proteins systematically lose their protective hydration shell when their environment becomes more acidic. Until recently, this was just a theory. State-of-the-art imaging techniques have helped researchers at Martin Luther University Halle-Wittenberg (MLU) directly observe this process for the first time at the level of the individual water molecule. This has answered a question in biochemistry that had remained unanswered for 50 years.
Synthesized peptides can slip into cells to block hard-to-target protein interactions
Many diseases are driven by proteins interacting with each other inside cells. But blocking these interactions with drugs is difficult because typical "small-molecule" drugs often prove to be too small to grip the broad, flat surfaces involved in protein-protein interactions.
'Bio-stickers' speed up plastic breakdown in marine environments
Plastic waste poses an urgent problem for the planet's ecosystems, especially in waterways. Millions of tons of plastic waste enter Earth's oceans every year, and plastic has been found in every part of the ocean, including at the bottom of the deepest ocean trenches.
Revised mushroom toxin pathway could improve poisoning detection
The St. George's mushroom (Calocybe gambosa) is a popular edible mushroom, usually picked in May. Unfortunately, however, it also carries a risk as it can easily be confused with the young deadly fiber cap, which can potentially lead to fatal poisoning. The reason for this is the mushroom toxin muscarine, which is present in high concentrations in the deadly fiber cap. Muscarine is best known from the fly agaric, in which it was first discovered.
New biosynthesis platform could enable bioactive compounds to be labeled, targeted and released on demand
Many medically important drugs originate from natural sources. Microorganisms produce these compounds using highly sophisticated and remarkably precise enzymatic assembly lines. Many natural microbial products belong to a class known as nonribosomal peptides—short chains of amino acids that often possess pharmacologically relevant biological activities, including antibiotic effects.